Death receptor 3 (nonfiction)

Human gene location of TNFRSF25 ("Death receptor 3").

Death receptor 3 (DR3), also known as "tumor necrosis factor receptor superfamily member 25" or (TNFRSF25), is a cell surface receptor of the tumor necrosis factor receptor superfamily which mediates apoptotic signalling and differentiation. Its only known TNFSF ligand is TNF-like protein 1A (TL1A).

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed preferentially by activated and antigen-experienced T lymphocytes.

Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported, most of which are potentially secreted molecules.

Therapeutic agonists of TNFRSF25 can be used to stimulate Treg expansion, which can reduce inflammation in experimental models of asthma, allogeneic solid organ transplantation and ocular keratitis.

Fiction cross-reference

• Gnomon algorithm
• Gnomon Chronicles

Nonfiction cross-reference

• Death (nonfiction)

External links:

• Death receptor 3 @ Wikipedia

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